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In Quarantine 2: Terminal, a residential building in Los Angeles is placed under quarantine by the police. At the same time, flight attendants Jenny and Paula from Trans Sky Air are preparing for their flight, TS Air 318, from Los Angeles to Kansas City. They are joined by Captain Forrest and Co-Pilot Wilsy.
On the flight, a teacher named Henry brings a cage of hamsters on board, but Jenny advises him to store them in the cargo hold. However, one of the hamsters bites a passenger named Ralph. Ralph quickly becomes ill and aggressive, attacking Paula. The male passengers intervene and lock Ralph in the bathroom.
Realizing the severity of the situation, Captain Forrest requests an emergency landing. However, upon arrival, they find that all the airport gates are closed. With no other option, Captain Forrest redirects the plane to an abandoned terminal. Employee Ed assists the crew and passengers in their efforts to find an exit, only to discover that the entire terminal is under quarantine. They are trapped with no way out.
As they navigate the terminal, the crew and passengers become increasingly desperate to escape. They encounter infected individuals, intense moments of suspense, and terrifying revelations about the origin of the quarantine. With time running out, they must find a way to survive and stop the spread of the mysterious infection before it claims their lives.
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